黎煥耀
(Huan-Yao Lei, Ph.D.)

小檔案

研究興趣

文章作品

Publication list (2001-2007) of Huan-Yao Lei

Immunology:

1.      Wang, J-Y., C-C. Shieh, C-K. Yu, and H-Y. Lei. 2001. Allergen-induced bronchial inflammation is associated with decreased levels of surfactant protein A and D in a murine model of asthma. Clin. Exp. Allergy 31: 652-662.

2.      Chen, C-L., C-T. Lee, Y-C. Liu, J-Y. Wang, H-Y. Lei, and C-K. Yu. 2003. House dust mite Dermatophagoides farinae augments proinflammatory mediator production and accessory function of alveolar macrophages: implications for allergic sensitization and inflammation. J. Immunol. 170: 528-536.

3.      Wang, Y-H., E-J. Lee, C-M. Wu, T-Y. Luh, C-K. Chou, and H-Y. Lei. 2004. Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene. J. Drug. Del. Sci. Tech. 14: 45-49.

4.      Chang, C-P., W-C. Cheng, and H-Y. Lei. 2005. A cellular ELISA to screen lectin-like compounds for cancer cell binding. Lett. Drug. Design. Discover. 2: 182-188.

5.      Chen, W-Y., Y-T Cheng, H-Y. Lei, C-P. Chang, C-W. Wang, and M-S. Chang. 2005. IL-24 inhibits the growth of hepatoma cells in vivo. Genes Immunity 6: 493-499.

6.      Huang, K-J., Y-C. Yang, Y-S. Lin, J-H. Huang, H-S. Liu, T-M. Yeh, S-H. Chen, C-C. Liu, and H-Y. Lei. 2006. The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J. Immunol. 176: 2825-2832.

Transplantation:

7.      Lee, P-C., C-J. Hung, Y-J. Lin, J-R. Wang, M-S. Jan, and H-Y. Lei. 2002. A role for chronic parvovirus B19 infection in renal transplant recipient. Transplantation 73:1635-1639.

8.      Lee, P-C., P.I. Terasaki, S.K. Takemoto, P-H. Lee, C-J. Hung, Y-L. Chen, A. Tsai, and H-Y. Lei. 2002. All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation 74: 1192-1194.

9.      Lee, P-C., Y-C. Tsai, C-J. Hung, Y-J. Lin, H-Y. Lei, J-J. Chuang, and K-S. Hsu. 2002. Induction of antinociception and increased Met-Enkephalin plasma levels by cyclosporine and morphine in rats: Implications of the combined use of cyclosporine and morphine and acute posttransplant neuropsychosis. J. Surg. Res. 106:1-6.

Clinical Investigation:

10.  Fan, Y-F., C-C. Lu, W-C. Chen, W-J Yao, H-C. Wang, T-T. Chang, H-Y. Lei, A-L. Shiau, and I-J. Su. 2001. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stage of chronic HBV infection Hepatology 33: 277-286. 

11.  Wang, S-M., C-C. Liu, Y-S. Huang, Y-J. Yang, and H-Y. Lei. 2001. Change in hepatitis A virus seroepidemiology in southern Taiwan: A large percentage of the population lack protective antibody. J. Med. Virol. 64: 104-108.

12.  Liu, M-F., S-C. Chao, C-R. Wang, and H-Y. Lei. 2001. Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment. Autoimmunity. 34: 107-113.

13.  Lin, Y-C., C-C. Lu, H-J. Su, C-Y. Shen, H-Y. Lei, and Y-L. Guo. 2002. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. Allergy 57: 831-834.

14.  Lin, Y-C. C-C. Lu, C-Y. Shen, H-Y. Lei, Y-L. Guo, and H-J. Su 2003. Roles of genotypes of beta2-adrenergic receptor in the relationship between eosinophil counts and lung function in Taiwanese adolescents. J. Asthma 40: 265-72.

15.  Hung, J-H., I-J. Su, H-Y. Lei, H-C. Wang, W-C. Lin, W-T. Chang, W-Y. Huang, W-C. Chang, Y-S. Chang, C-C. Chen, and M-D. Lai. 2004. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappa B and pp38 mitogen-activated protein kinase. J. Biol. Chem. 279: 46384-46392.

16.  Chang, C-P., M-C. Yang, H-S. Liu, Y-S. Lin, H-Y. Lei. 2007. Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology 45: 286-296.

17.  Lei, H-Y., C-P. Chang. 2007. Induction of autophagy by Concanavalin A and its application in anti-tumor therapy. Autophagy 3: 402-404.

Infection:

18.  Tsao, N., C-M. Wu, H-P. Hsu, C-C. Liu, T-Y Luh, C-K. Chou, and H-Y. Lei. 2001. Inhibition of the increased permeability of blood-brain barrier in Escherichia coli-induced meningitis by carboxyfullerene. Fulleren. Sci. Techol. 9:307-320.

19.  Tsao, N., T-Y. Luh, C-K. Chou, J-J Wu, Y-S. Lin, and H-Y. Lei. 2001. Inhibition of group A Streptococcal infection by carboxyfullerene. Antimicrob. Agents Chemother. 45: 1788-1793.

20.  Tsao, N. H-P. Hsu, C-M. Wu, C-C. Liu, and H-Y. Lei. 2001. TNF causes an increase in blood-brain barrier permeability during sepsis. J. Med. Microbiol. 50:812-821.

21.  Tsao, N., W-W. Chang, C-C. Liu, and H-Y. Lei. 2002. Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-a. FEMS Immunol. Med. Microbiol. 32:133-140.

22.  Tsao, N., T-Y. Luh, C-K. Chou, T-Y. Chang, J-J Wu, C-C. Liu, and H-Y. Lei. 2002. In vitro action of carboxyfullerene. J. Antimicrob. Chemother. 49:641-649.

23.  Wang, S-M., H-Y. Lei, K-J. Huang, J-M. Wu, J-R. Wang, C-K. Yu, I-J. Su, and C-C. Liu. 2003. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J. Infect. Dis. 188: 564-570.

24.  Chang, W-W, I.J. Su, M-D. Lai, W-T. Chang, W. Huang, and H-Y. Lei. 2003. The role of inducible nitric oxide synthase in a murine acute HBV infection model induced by hydrodynamics-based in vivo transfection of HBV-DNA. J. Hepatol. 39: 834-842.

25.  Wang, H-C., H-C. Wu, C-F. Chen, N. Fausto, H-Y. Lei, and I-J. Su. 2003. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am. J. Pathol. 163: 2411-2449.

26.  Tseng, K-C., H-Y. Lei, P-N. Cheng, K-C. Young, C-M. Jen, C-H. Wu, and T-T. Chang. 2003. Immune response to hepatitis B vaccine of subjects with isolated antibody to hepatitis B core antigen. Hepato-Gastroenterology. 50: 1474-1477.

27.  Chen, Y-C., C-K. Yu, Y-F. Wang, C-C Liu, I-J Su, and H-Y. Lei. 2004. A murine oral enterovirus 71 infection model with central nervous system involvement. J. Gen. Virol. 85: 69-77.

28.  Wang, Y-F, C-T. Chou, H-Y. Lei, C-C. Liu, S-M. Wang, J-J. Yan, I-J. Su, J-R. Wang, T-M. Yeh, S-H. Chen, and C-K. Yu. 2004. A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J. Virol. 78: 7916-7924.

29.  Kuo C-F., Y-H. Luo, H-Y. Lin, K-J. Huang, J-J. Wu, H-Y. Lei, M-T. Lin, W-J. Chuang, C-C. Liu, Y-T. Jin, and Y-S. Lin. 2004. Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. Microbial Pathogen. 36; 273–285.

30.  Hsieh, Y-H., I-J. Su, H-C. Wang, W-W. Chang, H-Y. Lei, M-D. Lai, W-T. Chang, and W-Y. Huang. 2004. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 25: 2023-2032.

31.  Liang, C-C., M-J. Sung, H-Y. Lei, S-H. Chen, C-K. Yu, C-C. Liu, J-R. Wang, and T-M. Yeh. 2004. Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. J. Med. Virol. 74: 597-603.

32.  Wang, H-C., W-T. Chang, W-W. Chang, H-C. Wu, W-Y. Huang, H-Y. Lei, M-D. Lai, N. Fausto, and I-J. Su. 2005. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 41: 761-770.

33.  Huang, K-J., I-J. Su, M. Theron, Y-C. Wu, S-K. Lai, C-C. Liu, and H-Y. Lei. 2005. An interferon-g-related cytokine storm in SARS patients. J. Med. Virol. 75: 185-194.

34.  Weng, T-Y., L-C. Chen, H-W. Shyu, S-H. Chen, J-R. Wang, C-K. Yu, H-Y. Lei, and T-M. Yeh. Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells. Antiviral Res. 67: 31-37.

35.  Wang, S-M., H-Y. Lei, M-C. Huang, J-M. Wu, C-T. Chen, J-N. Wang, J-R. Wang, and C-C. Liu. 2005. Therapeutic efficacy of Milrinone in the management of enterovirus 71-induced pulmonary edema. Pediatr. Pulmonol. 39: 219-223.

36.  Chang, W-W., I-J. Su, M-D. Lai, W-T. Chang, W-Y. Huang, and H-Y. Lei. 2005. Toll-like receptor 4 plays an anti-HBV role in a murine model of acute hepatitis B virus expression. World J. Gastroentero. 11: 6631-6637.

37.  Theron, M., K-J Huang, Y-W. Chen, C-C. Liu, and H-Y. Lei. 2005. A probable role for IFN-g in the development of a lung immunopathology in SARS. Cytokine 32: 30-38.

38.  Lin, Y-S., C-F. Lin, Y-F. Fang, Y-M. Kuo, P-C. Liao, T-M. Yeh, K-Y. Hwa, C-K. Shieh, J-H. Yen, H-J. Wang, I-J. Su, and H-Y. Lei. 2005. Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and cause cytotoxicity. Clin. Exp. Immunol. 141: 500-508.

39.  Cheng, T-L., W-W. Chang, I-J. Su, M-D. Lai, W. Huang, H-Y. Lei, and W-T. Chang. 2005. Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference. Biochem. Biohys. Res. Com. 336: 820-830.

40.  Chen, L-C., H-W. Shyu, S-H. Chen, H-Y. Lei, C-K. Yu, and T-M. Yeh. 2005. Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells. J. Med. Virol. (in press).

Dengue virus:

41.  Lin, C-F., H-Y. Lei, C-C. Liu, H-S. Liu, T-M. Yeh, S-T. Wang, T-I. Yang, F-C. Sheu, C-F. Kuo, and Y-S. Lin. 2001. Generation of IgM anti-platelet autoantibody in dengue patients. J. Med. Virol. 63: 143-149.

42.  Huang, Y-H., C-C.Liu, S-T. Wang, H-Y. Lei, H-S. Liu, Y-S. Lin, H-L. Wu, and T-M. Yeh. 2001. Activation of coagulation and fibrinolysis during dengue virus infection. J. Med. Virol. 63: 247-251.

43.  Lei, H.Y., T.M. Yeh, H.S. Liu, Y.S. Lin, S.H. Chen, and C.C. Liu. 2001. Immunopathogenesis of dengue virus infection J. Biomed. Sci. 8:377-388.

44.  Lin, C-F., H-Y. Lei, A-L. Shiau, H-S. Liu, T-M. Yeh, S-H. Chen, C-C. Liu, S-C. Chiu, and Y-S. Lin. 2002. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of NO. J. Immunol. 169:657-664.

45.  Liu, C-C., K-J. Huang, Y-S. Lin, T-M. Yeh, H-S. Liu, and H-Y. Lei. 2002. Transient CD4/CD8 ratio inversion and immune deviation during dengue virus infection. J. Med. Virol. 68: 241-252.

46.  Lin, Y-L., H-Y. Lei, Y-S. Lin, T-M. Yeh, S-H. Chen, and H-S. Liu. 2002. Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res. 56: 93-96.

47.  Wang, S-H., W-J. Syu, K-J. Huang, H-Y. Lei, C-W. Yao, C-C. King, and S-T. Hu. 2002. Intracellular localization and determination of a nuclear localization signal of the core protein of dengue virus. J. Gen. Virol. 83:3093-3102.

48.  Lin, Y-W., K-J. Wang, H-Y. Lei, Y-S. Lin, T-M. Yeh, H-S. Liu, C-C. Liu, and S-H. Chen. 2002. Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J. Virol. 76: 12242-12249.

49.  Lei, H-Y., J-H. Huang, K-J. Huang, and C-M. Chang. 2002. Current status of dengue control programme in Taiwan -2001. Dengue Bullitin 26: 14-23.

50.  Lin, C-F., H-Y. Lei, A-L. Shiau, C-C. Liu, H-S. Liu, T-M. Yeh, S-H. Chen, and Y-S. Lin. 2003. Antibodies from dengue patient sera cross-react with endothelial cell and induce damage. J. Med. Virol. 69: 82-90.

51.  Huang, Y.-H., H-Y. Lei, H-S., Liu, Y-S. Lin, S-H. Chen, C-C. Liu, and T-M. Yeh. 2003. Tissue plasminogen activator induced by dengue virus infection of human endothelial cells. J. Med. Virol. 70: 610-616.

52.  Hung, N.T., H-Y. Lei, N.T. Lan, Y-S. Lin, K-J. Huang, L. B. Lien, C-F. Lin, T-M. Yeh, D.Q. Ha, V. T. Q. Huong, L-C. Chen, J.-H. Huang, L. T. My, C-C. Liu, and S. B. Halstead. 2004. Dengue hemorrhagic fever in infants: A study on clinical and cytokine profiles. J. Infect. Dis. 189: 221-232.

53.  Lin, C-F. H-Y. Lei, C-C. Liu, H-S. Liu, T-M. Yeh, S-H. Chen, and Y-S. Lin, 2004. Autoimmunity in dengue virus infection. Dengue Bulletin 28: 51-57.

54.  Lin, Y-S., C-F. Lin, H-Y. Lei, H-S. Liu, T-M. Yeh, S-H. Chen, and C-C. Liu. 2004. Antibody-mediated endothelial cell damage via nitric oxide. Curr. Pharmaceut. Design. 10: 213-221.

55.  Nguyen, T.H., T.L. Nguyen, H-Y. Lei, Y-S. Lin, B.L. Le, K-J. Huang, C-F. Lin, Q.H. Do, T.Q. Vu, T.M. Lam, T-M. Yeh, J-H. Huang, C-C. Liu, and S.B. Halstead. 2005. Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. Amer. J. Trop. Med. Hyg. 72: 370-374.

56.  Lin, C-F., S-C. Chiu, Y-L. Hsiao, S-W. Wan, H-Y. Lei, A-L. Shiau, H-S. Liu, T-M. Yeh, S-H. Chen, C-C. Liu, and Y-S. Lin. 2005. Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J. Immunol. 174: 395-403.

57.  Lee, Y-R., K-J. Huang, H-Y. Lei, S-H. Chen, Y-S. Lin, T-M. Yeh, and H-S. Liu. 2005. Suckling mice were used to detect infectious dengue-2 viruses by intracerebral injection of the full-length RNA transcript. Intervirology 48: 161-166.

58.  Huang, K-J., Y-C. Yang, Y-S. Lin, H-S. Liu, T-M. Yeh, S-H. Chen, C-C. Liu, and H-Y. Lei. 2005. Flow cytometric determination for dengue virus-infected cells: Its application for antibody-dependent enhancement study. Dengue Bulletin 29: 142-150.

59.  Huang, K-J., Y-C. Yang, Y-S. Lin, J-H. Huang, H-S. Liu, T-M. Yeh, S-H. Chen, C-C. Liu, and H-Y. Lei. 2006. The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J. Immunol. 176: 2825-2832.

60.  Chen, L-C., H-Y. Lei, C-C. Liu, S-C. Shiesh, S-H. Chen, H-S. Liu, Y-S. Lin, S-T. Wang, H-W. Shyu, and T-M. Yeh. 2006. Serum levels of macrophage migration inhibitory factor correlate with disease severity and clinical outcome in dengue patients. Am. J. Trop. Med. Hyg. 74: 142-147.

61.  Nguyen, T.H., T.L. Nguyen, H-Y. Lei, Y-S. Lin, B.L. Le, K-J. Huang, C-F. Lin, Q.H. Do, T.Q. Vu, T.M. Lam, T-M. Yeh, J-H. Huang, C-C. Liu, and S.B. Halstead. 2006. Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. Amer. J. Trop. Med. Hyg. 74: 684-691.